My Top 3 Supplements for the Brain - Lakeside Natural Medicine -Lakeside Natural Medicine

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My Top 3 Supplements for the Brain

BySarah Axtell, ND November 14, 2025

  1. Fish oil:  Fish oil is especially important if you carry the APOE4 gene (Alzheimer’s gene). Lower blood omega 3 levels are correlated with worse cognitive function. The APOE4 brain is actually pulling more DHA from the plasma and concentrating it in the brain in order to function normally.  DHA protects neurons and increases cell membrane fluidity, which can protect against the beta-amyloid plaques and tau tangles implicated in Alzheimer’s disease. This DHA-dominant formula offers targeted support for membrane function within the brain.
  2. Curcumin Phytosome: A growing body of evidence indicates that oxidative stress and inflammation contribute to the pathophysiology of Alzheimer’s disease. Curcumin can combat this oxidative stress and reduce inflammation in the brain, enhancing mood and memory. As a phytosome complex, this particular curcumin provides superior absorption over other curcumin extracts.
  3. Lion’s Mane: The mushroom’s capacity to stimulate nerve growth factor (NGF) synthesis has highlighted its potential in preventing and managing neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. In addition to Lion’s Mane promoting mental clarity, focus, and memory, it can also support a healthy immune system.

Want brand and dosing specifics? I discuss how to take these supplements along with my favorite brands in my Brain Health Course.

Editor’s Note: The information in this article is intended for your educational use only. Always seek the advice of your physician or other qualified health practitioners with any questions you may have regarding a medical condition and before undertaking any diet, supplement, fitness, or other health program.


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