The Hidden Link Between Menopause and Alzheimer’s: What You Need to Know
BySarah Axtell, ND •October 7, 2025

Women carry 2x the risk of developing Alzheimer’s compared to men. In fact, a woman’s estimated lifetime risk of developing Alzheimer’s at age 65 is 1 in 5. It’s projected that this figure will double by the year 2050! Let’s change that trajectory. First, it’s crucial to understand underlying risk factors, including changes in hormones.
A common symptom among menopausal women is memory loss and brain fog. Hormones influence how brain cells communicate and function, impacting things like mood, memory, focus, and sleep.
Estrogen in particular plays a protective role in the brain- reducing oxidative stress, influencing how the brain gets fuel, and fighting inflammation. During menopause, declining estrogen levels can create a vulnerability to memory loss, triggering the accumulation of damaging proteins (beta-amyloid and tau proteins). While many women navigate this transition without lasting damage, those with a genetic predisposition (ApoE4) may benefit from considering hormone replacement therapy.
Hormone replacement therapy (HRT) can do more than reduce menopause symptoms- it can protect your brain health. According to a recent study, women taking estrogen replacement mid-life have a 32% reduction in the risk of developing Alzheimer’s or dementia.
So as a perimenopausal or postmenopausal woman, what can you do to support your brain health?
HRT is worth having a discussion with your doctor if you are a candidate. The good news is that nutrition also plays a critical role in preventing dementia. By incorporating brain-healthy foods into your diet, you can take proactive steps towards reducing your risk.
In my upcoming Brain Health Group Visit, we’ll explore the power of food as medicine and discuss strategies for using nutrition to prevent dementia. Join me to learn more about how you can take control of your brain health and reduce your risk of Alzheimer’s.
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Editor’s Note: The information in this article is intended for your educational use only. Always seek the advice of your physician or other qualified health practitioners with any questions you may have regarding a medical condition and before undertaking any diet, supplement, fitness, or other health program.